PF 431396 ( PF-431396; PF 431396; PF431396 )

产品货号. M19031 CAS No. 717906-29-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

PF 431396
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
产品描述

PF-431396 is a potent and selective focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).
同义词

PF-431396; PF 431396; PF431396
通路

Others
靶点

Other Targets
受体

FAK; PYK2
研究领域

Endocrinology
适应症

——

CAS Number

717906-29-1
分子量

506.5
分子式

C22H21F3N6O3S
纯度

98%
溶解度

——
SMILES

n1c(nc(c(c1)C(F)(F)F)NCc1c(cccc1)N(C)S(=O)(=O)C)Nc1ccc2c(c1)CC(=O)N2
化学全称

N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

1. Han S, et al. J Biol Chem. 2009, 284(19), 13193-13201.

计算器

产品手册

关联产品

Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
DTNB

DTNB is used to quantify the number or concentration of thiol groups in a sample. It also can be used for measuring low-molecular-mass thiols such as glutathione in both pure solutions and biological samples.such as blood.